Process of preparing bismuth beta-naphtholate.



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JOSEPH L. TURNER, OF PHILADELPHIA, PENNSYLVANIA, AND CHARLES E. VANDER-KLEED, OF COLLINGSWOOD, NEW JERSEY, ASSIGNORS T H. K. MULFORD COMPANY,OF PHILADELPHIA, PENNSYLVANIA, A CORPORATION OF PENNSYLVANIA.

PROCESS OF PREPARING BISlVIUTI-I BETA-NAPHTHOLATE.

985,559. Specification of Letters Patent Patented Feb. 28, 1911.

No Drawing. Application filed September 14, 1909. Serial No. 517,572.

To all whom it may concern: boiled for from eight to ten hours under 55Be it known that we, JosEPH L. TURNER, a constant stirring. Theprecipitate is then subject of the Czar of Russia, and CHARLES left tosettle, the supernatant liquid is de- E. VANDERKLEED, a citizen of theUnited canted and the precipitate is washed by States, residing,respectively, in Philadelfiltration until the washings cease to showphia, Pennsylvania, and Oollingswood, New an alkaline reaction. Theprecipitate is 60 Jersey, have invented certain Improvements finallydried at a moderate temperature. in Processes for Preparing BismuthBeta- The product resulting from the above de- Naphtholate, of which thefollowing is a scribed process is the desired compound of specification.bismuth and beta-naphthol, which is a valu- The object of our inventionis to provide able intestinal antiseptic possessing the 65 a process forpreparing an antiseptic comqualities above indicated. pound for internaluse which shall consist As illustrating the distinctive characterofbeta-naphthol in combination with bisistics of the product prepared byour procl5 Inuth oXid and shall not possess the objecess, if a givenweight of said product be tionable taste and corrosive qualitiescharextracted with chloroform, evaporated care- 7 v acterizingbeta-naphthol. fully to dryness in a weighed flask and the Anotherobject of our invention is to proresidue weighed, it will be found thatsaid duce an antiseptic containing about 75% of Pr yle ds only lO llt(16% Of SXtIaC- 20 bismuth oxid and about 23% of b taa htive. It willfurther be noted that the thol in true chemical combination; th productobtained in the above determina- 75 compound, o over b in o r ar d tionpresents a crystalline appearance, is that it shall not contain any ofthe decomready sublimable, and has a melting point position products ofthe beta-naphthol. of about 122 C.

25 In carrying out our invention, we first We cla1m:-

convert the beta-naphthol into its sodium salt 1. The process ofpreparing the herein 80 by dissolving it in the theoretical amount ofdescribed compound of bismuth and betasodium hydroxid. We then add tothis sonaphthol which consists in converting betalution a solutionobtained by dissOlVing naphthol into one of its alkaline salts; actingcrystals f bi th it t i acetic acid, on said compound with an acidsolution of then neutralize the nitric acid freed from bismuth nitrate;neutralizing the resulting 85 the bismuth nitrate and also the aceticacid, Solution; boiling said solution; and separatby a further additionof sodium hydroxid ing therefrom the compound of bismuth solution. Theprecipitate obtained by this and beta-naphthol.

process is a brownish gray powder contain- 2. The process of preparingthe herein ing about 23% of beta-naphthol in combinadescribed compoundof bismuth and beta- 9 tion with bismuth oXid, the reactions naphtholwhich consists in acting on betawhich occur in its formation being asfolnaphthol with a solution of sodium hylows: droxid;badding 1theretothe solution ob- 40 tained disso vin bismuth nitrate inCH7fOH+NaOH:C1H7'ONa+H2O acetic acitl; neutralizing the resultingsoluaigjggg OH +6NaN03 +1120 tion; boilingsaid solution; and separatingV the precipitate formed. In actually carrying out the process, we 3.The process of preparing the herein 45 employ, for example, twenty-fivepounds of described compound of bismuth and betabeta-naphthol dissovledin a solution of naphthol which consists in dissolving betatwenty-eightpounds of sodium hydroxid in naphthol in a solution of sodium hytwentygallons of water. To this we add, droxid and water; adding to saidsolufirst, a solution of 84 pounds of bismuth tion a second solution ofbismuth nitrate 50 nitrate in a mixture of one hundred pounds and amixture of acetic acid and water;

glacial acetic acid and eleven gallons of then adding a further amountof sodium water, and then gradually add a solution of hydroxid; boilingthe combined solutions; sixty-two pounds of sodium hydroxid in andseparating the precipitate formed.

ten gallons of water, the whole being then 4. The process of preparingthe heroin described compound of bismuth and beta- -naphthol whichconsists in dissolving 25 pounds of beta-naphthol in a solution of 28pounds of sodiunrhydroxid in 20 gallons of Water; adding to the same,first a solution of Set pounds of bismuth nitrate and 100 pounds ofglacial acetic acid in 11 gallons of Water, and then a solution of 62pounds of sodium hydroXid in 10 gallons of Water;

10 boiling the solutions and separating out the 1 resulting precipitate;the proportions of the ingredients being substantially as specified. Intestimony whereof, W6 have signed our names to this specification in thepresence of two subscribing Witnesses.

JOSEPH L. TURNER. CHARLES E. VANDERKLEED. \Vitnesses:

TILLIAM E. BRADLEY, VM. A. BARR.

Copies of this patent may be obtained for five cents each, by addressingthe Commissioner of Patents,

Washington, D. G.

